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Univariate and multivariate analyses were performed to determine the value of hrm parameters in predicting abnormal esophageal reflux burden. These disruptions can contribute to the development of gerd and related symptoms. Univariate and multivariate analyses addressed performance of esophageal body and egj metrics in predicting abnormal esophageal reflux burden, and symptom outcome from antireflux therapy.

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This study aimed to evaluate the relationships between manometric egj metrics with esophageal acid exposure. Disruptions in the egj barrier can arise from motor deficiency (hypotensive egj), morphological abnormalities (hiatus hernia), or a combination of both factors Structural disruption of the esophagogastric junction (egj) barrier, and incomplete clearance of the refluxate can contribute to abnormally high esophageal reflux burden that defines gerd.